Item Type:ArticleItem Status:Live ArchiveAbstractThe prion protein, PrPC, is a small, cell surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known as prion diseases. A hallmark of prion diseases is the conversion of PrPC into an abnormally folded isoform, which provides a template for further pathogenic conversion of PrPC, allowing disease to spread from cell to cell and, in some circumstances, to transfer to a new host. In addition to the putative neurotoxicity caused by the misfolded form(s), loss of normal PrPC function could be an integral part of the neurodegenerative processes and, consequently, significant research efforts have been directed toward determining the physiological functions of PrPC.
Since Black Friday has just so so prices on big name TVs, and the iPhone can be purchased without requiring anyone to wait in lines, it would seem to be pretty easy to demonstrate that the emperor has no clothes. Instead, thanks to brilliant marketing and the stubborn crowd mentality, Daniel M. Ladik, a marketing professor at the Stillman School of Business at Seton Hall University, tells MarketWatch that he thinks lines for the newest, most buzzworthy products are here to stay:.
“I am warning you: Alina must not leave Cuba under any pretext or in any way,” Castro told his head bodyguard, Col. Jose Delgado Castro, according to Sanchez. “You’ve been warned.” Two months later, Alina put on a wig, packed a false Spanish passport, and, with the help of a network of international accomplices, sneaked out of Cuba.
“We discovered early on our female clients have unique needs. They look for more collaborative, education focused advisers with a holistic, long term approach to financial planning,” said Jennifer Boynton, an investment counsel at Toronto based RealGrowth, which is growing by focusing on addressing the needs of female clients. “Addressing these needs, while still meeting their investment targets, has enabled us to consistently exceed acquisition, retention, and most importantly, client satisfaction goals,” she said..
There are some things we never want to touch and others we want to know more about. But our power could actually be the ability to inscribe a boundary around what we decide to include or exclude. What are we including when we go to design a thing? What are we excluding? And are there other ways of thinking? Are there other types of knowledge we could get that if we developed other ways of working? Our vision to this practice is a design philosophy.”.